Efficacy of cetuximab combined with chemotherapy on advanced colorectal cancer:a report of 53 cases
10.3321/j.issn:1000-467X.2009.12.015
- VernacularTitle:西妥昔单抗联合化疗对53例晚期结直肠癌的疗效
- Author:
Guo GUI-FANG
1
,
2
;
Xia LIANG-PING
;
Zhang BEI
;
Jiang WEN-QI
;
Liu MAO-ZHEN
;
Hu PEI-LI
;
Chen XU-XIAN
;
Qiu HUI-JUAN
;
Zhou FEI-FEI
Author Information
1. 华南肿瘤学国家重点实验室,广东,广州,510060
2. 中山大学肿瘤防治中心综合科,广东,广州,510060
- Keywords:
centuximab;
advanced colorectal cancer;
short-term efficacy;
prognosis;
safety
- From:Chinese Journal of Cancer
2009;28(12):1317-1323
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: Studies showed that cetuximab combined with chemotherapy was effective on advanced colorectal cancer (ACRC)in recent years,however,few reports based on large case cohort are available in China.This study was to analyze the efficacy of cetuximab combined with chemotherapy for 53 chinese patients with ACRC. Melhods:Clinical data of 53 patients with ACRC.treated with cetuximab combined with chemotherapy in Sun Yat-sen Cancer Center from March 2005 to April 2008,were analyzed for short-term efficacy and safety.The efficacy of the regimen used as first-line and non-first-line treatment was compared by Chi-square test;the effect of the regimen on prognosis was analyzed by multivariate Cox proportional hazards model.Results:Of the 53 patients with colorectal adenocarcinoma,40 were men and 13 were women, with a median age of 55 years. A total of 572 weeks(median,8 weeks) of cetuximab treatment were completed.The overall response rate(RR)of the regimen was 39.6%and the disease centrel rate 66.0%.The disease control rates were similar when the regimen was used as first-line and non-first-line treatment(80.3%MS.60.5%,P=0.177).For all 53 patients,clinical stage was an independent prognostic factor(P=0.002,OR>1).The most common Grade 3 to 4 adverse events included acne-like rash(7.5%),neutropenia (18.9%), and diarrhea (5.6%). No hypersensitive reaction or treatmentrelated death was observed. Only one patient discontinued treatment because of Grade 4 diarrhea and neutopenia. Conclusions: Cetuximab combined with chemotherapy can achieve relatively high disease control rate for ACRC patients.with less adverse events.Whether cetuximab has better effect in first-line treatment than in non-first-line treatment needs further study.
