Intranasal administration of temozolomide for brain-targeting delivery：therapeutic effect on glioma in rats
- VernacularTitle:经鼻腔给药的替莫唑胺脑靶向制剂对大鼠胶质瘤的治疗效果
- Author:
Ying LI
1
;
Yongliang GAO
;
Gang LIU
;
Xiudi ZHOU
;
Yan WANG
;
Yulin WANG
;
Lin MA
Author Information
1. 解放军总医院放射科
- Keywords:
glioma;
temozolomide;
magnetic resonance imaging;
brain targeting delivery
- From:
Journal of Southern Medical University
2014;(5):631-635
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect of intranasal administration of temozolomide (TMZ) for brain-targeting delivery in a rat model bearing orthotopic C6 glioma xenografts. Methods Forty Wistar rat bearing brain C6 glioma xenograft were randomly divided into 4 groups and treated with physiological saline solution or with TMZ by intravenous injection, gavage or intranasal administration. The tumor size, rat survival time and pathological changes were observed in each group. Results Magnetic resonance imaging showed a significantly reduced volume of glioma in intranasal TMZ group compared with that in the control, intraveneous TMZ injection group and TMZ gavage groups (12.45±2.49 mm3 vs 60.16±4.12, 33.17±3.56, and 35.16±4.36 mm3, respectively, P<0.05). The median survival time of the C6 glioma-bearing rats was also significantly longer in intranasal TMZ group than in the other 3 groups (31.0 days vs 20, 19, and 21.5 days, respectively, P<0.05). In the glioma xenografts, PCNA expression was the lowest and tumor cell apoptosis rate the highest in intranasal TMZ group. Conclusion Intranasal TMZ administration can suppress the growth of C6 glioma in rats and may serve as an effective strategy for glioma treatment.
