Efficacy and survival of 92 cases of Ewing's sarcoma family of tumor initially treated with multidisciplinary therapy
10.3321/j.issn:1000-467X.2009.12.013
- VernacularTitle:92例初治尤文氏肉瘤家族肿瘤综合治疗疗效和生存分析
- Author:
Peng ROU-JUN
1
;
Sun XIAO-FEI
;
Xiang XIAO-JUAN
;
Zhen ZI-JUN
;
Ling JIA-YU
;
Tong GANG-LING
;
Xia YI
;
Xu GUANG-CHUANG
;
Jiang WEN-QI
Author Information
1. 中山大学肿瘤防治中心
- Keywords:
Ewing's sarcoma family of tumor;
Ewing's sarcoma;
primitive neuroectodermal tumor;
Askin tumor;
multimodal therapy;
survival analysis
- From:Chinese Journal of Cancer
2009;28(12):1304-1309
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: Ewing's sarcoma family of tumor (ESFT)is aggressive.The optimal therapy modality for ESFT is still to be found.This study was to explore the clinicaI characteristjcs and therapy for ESFT.Methods:Ninety-two cases of ESFT were collected from January 1995 to April 2008 in Sun Yat-sen University Cancer Center and analyzed retrospectively.Result:Of 92 cases,23 were Ewing's sarcoma of bone,21 extraosseous Ewing's sarcoma,43 peripheral primitive neuroectodermal tumor,and 5 Askin tumor.Median follow-up time was 31.5 months(range,10-137months).Thirty-eight patients received multidisciplinary therapy and 19 single model therapy in non-metastasis group.Three-year overall survival (OS) and event-free survival (EFS) were significantly different between non-metastatic multidisciplinary therapy group and non-metastatic single model group(63%vs.20%.46%vs.18%,respectively,P<0.001).The patients who received surgery plus chemotherapy and plus radiation or not had longer survival than those treated with chemotherapy plus radiation in non-metastatic multidisciplinary therapy group(χ~2=7.591, 9.212;P=0.006,0.002).CAV/IE alternative regimen was superior to other regimens in event-free survival,but not in overall survival(χ~2=6.950,3.530;P=0.008,0.06).Cox regression analysis suggested therapy model and response to treatment were independent prognostic factors for ESFT.Conclusions:Our studying showed multidisciplinary therapy could significantly improve non-metastatic ESFT patients'survival.Chemotherapy plus surgery and plus radiation or not were superior to chemotherapy plus radiation in local control for the non-metastatic ESFT,Therapy model and response were independent prognostic factors.
