The 2-year mortality of early captopril administration in 7 079 patients with acute myocardial infarction: long-term follow-up from Chinese Cardiac Study (CCS-1
10.3760/j:issn:0253-3758.2001.01.007
- VernacularTitle:卡托普利早期应用对心肌梗死患者远期病死率的影响——中国心脏研究-Ⅰ远期随访7 079例报告
- Author:
Lisheng LIU
1
Author Information
1. Cardiovascular Institute and Fu Wai Hospital
- From:
Chinese Journal of Cardiology
2001;29(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the 2-year mortality of early captopril administration in patients with acute myocardial infarction. Methods Seven thousand and seventy-nine patients with acute myocardial infarction were selected to follow-up from the collaborative hospital which finished more than 20 cases observation in CCS-I study. 76% were male and 24% were female. The mean age were 63.6±10.6 years. The follow-up rate was 88.5%. The mean follow-up period were 23.3±16.9 months. Results The main baseline characteristics between the captopril group (n=3 554) and placebo group (n=3 525) were similar. During nearly 2-year follow-up, 568 (16.0%) cumulative deaths occurred in captopril group compared with 631 (17.9%) cumulative deaths in placebo group. This 10.6% proportional reduction in deaths was statistically significant (P=0.03). Cardiovascular deaths in captopril group (14.7%) was lower than that in placebo group (16.0%) (P=0.03), especially deaths due to heart failure ( 4.5% vs 6.0%) were more significantly different (P=0.004). Early captopril administration in acute myocardial patients could save 19 patients per 1 000 patients in 2-year follow-up. Early mortality in captopril group (9.0% vs 9.6%) was decreased about 6.3%, but long-term mortality (7.0% vs 8.3%) was decreased by 15.7% (P=0.05), especially deaths from heart failure was more significantly reduced. Conclusion Early administration of captopril can significantly reduce the cumulative mortality and long-term mortality in patients with acute myocardial infarction.
