Relationship between tumor necrosis factor β gene polymorphism and acute respiratory distress syndrome after operation for esophageal carcinoma
10.3321/j.issn:1000-467X.2009.12.005
- VernacularTitle:肿瘤坏死因子β基因多态性与食管癌术后并发急性呼吸窘迫综合征的相关性
- Author:
Liu LI-XIA
1
;
You XUE-JIAN
;
Zhang YU-XIANG
;
Zhao CHAI
;
Chen LEI
;
Hu ZHEN-JIE
Author Information
1. 河北医科大学第四医院
- Keywords:
acute respiratory distress syndrome;
tumor necrosis factor β;
gene polymorphism;
esophageal cancer
- From:Chinese Journal of Cancer
2009;28(12):1255-1259
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective:A single nucleotide polymorphism of the tumor necrosis factor β(TNFβ)gene affected the level of tumor necrosis factor α and was associated with prognosis of acute respiratory distress syndrome(ARDS).This study was to investigate the association between the TNFβ and ARDS after operation for esophageal carcinoma.Methods:Thinyfour patients with and 116 patients without ARDS after radicaI resection for thoracotomic esophageal carcinoma were recruited in the Fourth Hospital of Hebei Medical University from January 2005 to June 2007.Peripheral blood samples were collected and DNA extracted.TNFβ genotype was determined by restriction fragment length polymorphism(RPLF).Results:There was no significant difference between the two groups in the TNFβ genotype and allele frequency (P>0.05).The time of mechanicaI ventilation was shorter and that of staying in the intesive care unit was longer for ARDS patients with the 1/2 genotype in the TNFβ than for those with other genotypes ( both P< 0.05).The frequency of the 1/1 genotype and 1 allele in the TNFβ was significantly higher in the group of surviving patients with ARDS than in the group of death patients.The odd ratios for mortality of two groups were 16.5 and 11.2, respectively. Conclusions: TNFβ did not appear to be a contributing factor influencing the morbidity of the patients with ARDS after operation for esophageal carcinoma,however, it might affect the development and prognosis of ARDS.
