Impact of a history of novel coronavirus infection on the clinical characteristics of children with rhinovirus infection
10.3760/cma.j.cn112866-20240809-00116
- VernacularTitle:新型冠状病毒感染史对鼻病毒感染患儿临床特征的影响
- Author:
Shu TENG
1
;
Zhenghong QI
;
Wen LI
;
Huaping WANG
;
Shiyong ZHAO
;
Mengfei YU
Author Information
1. 杭州市儿童医院感染肝病科，杭州 310014
- Keywords:
Rhinovirus;
Novel coronavirus;
Clinical features;
Children
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(5):564-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to clarify the clinical characteristics of children infected with rhinovirus in the context of the Corona Virus Disease 2019 (COVID-19) pandemic and to explore the impact of recent COVID-19 infection history on their clinical features.Methods:Clinical data and laboratory test result of 286 children diagnosed with rhinovirus infection at Hangzhou Children′s Hospital from July 2022 to October 2023 were collected. A retrospective survey was conducted to determine whether all study participants had a history of COVID-19 infection within the 6 months prior to hospitalization.Results:Among the 286 children with rhinovirus infection, 180 (62.94%) had simple rhinovirus infection, while 106 (37.06%) had co-infections with other pathogens; Among the 180 rhinovirus simplex-positive children, 56.67% had wheezing symptoms; among them, 15 cases (15/180, 8.33%) were diagnosed with acute asthma attacks; 7 cases (7/180, 3.88%) were diagnosed with severe pneumonia. Based on whether the children had a history of COVID-19 infection in the 6 months prior to hospitalization, they were divided into a group with previous COVID-19 infection and a group without previous COVID-19 infection. There were no significant differences between the two groups in terms of gender, age of onset, peak fever, incidence of wheezing, incidence of pneumonia, proportion of severe pneumonia, proportion of severe asthma attacks, duration of fever, time to relief of wheezing, length of stay, white blood cell count, eosinophil count, C-reactive protein, procalcitonin, immunoglobulin E, oxygen therapy requirements, and use of intravenous steroids ( P>0.05). Conclusions:A history of COVID-19 infection in the past 6 months does not exacerbate the clinical symptoms of children with rhinovirus infection, nor does it increase the incidence of wheezing.
