Clinicopathologic features and Epstein-Barr virus infection status of Burkitt's lymphoma in Guangzhou district
10.3321/j.issn:1000-467X.2009.08.003
- VernacularTitle:广州地区Burkitt's淋巴瘤的临床病理特征及EB病毒感染状况
- Author:
Huang YUHUA
1
,
2
;
Wu QIU-LIANG
;
Zong YONG-SHENG
;
Feng YAN-FEN
;
Liang JIAN-ZHONG
;
Hou JING-HUI
;
Shao QIONG
;
Fu JIA
Author Information
1. 华南肿瘤学国家重点实验室,广东广州510060
2. 中山大学肿瘤防治中心病理科,广东广州510060
- Keywords:
Burkitt's lymphoma;
clinicopathologic features;
Epstein-Barr virus;
immunophenotype
- From:Chinese Journal of Cancer
2009;28(8):805-812,插2
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: Sporadic Burkitt's lymphoma (sBL) is uncommon and its relation to Epstein-Barr virus (EBV) is unknown in China.This study was to investigate the clinical presentation, morphologic features,immunophenotype and EBV infection status of sBL in Guangzhou district, a prevalent area of EBV infection. Methods: The clinical data of 21 sBL patients were reviewed. A panel of immunohistochemical staining was performed and EBV-encoded small RNAs (EBERs) in situ hybridization was applied to identify EBV infection. Results: From January 2000 to October 2007, 21 cases (0.87%) of sBL were confirmed among 2416 cases of non-Hodgkin's lymphoma (NHL) in Sun Yat-sen University Cancer Center. Male to female ratio was 4.25 (17/4). The median age was 23 years. Of the 21 patients, 19 (90.48%) had lymph node(s) involvement; 16 (76.19%) had multiple sites involvement; 12 (57.14%) were at advanced stages (Ⅲ/Ⅳ). The 2-year survival rate of 15 patients who received chemotherapy or resection plus chemotherapy was 56.00%. Twenty cases showed the prototypic morphology of sBL, and one was the variant of sBL with plasmacytoid differentiation. The main immunophenotype of these 21 sBLs was slgM+/CD20+/CD10+/Bcl-6+/Bcl-2-[or Bcl-6+(>95%)/Bcl-2+(<10%)]/TdT-/Ki-67+ 100%. Of 20 detectable cases, 11 showed CD5 expression in a few (3%-20%) tumor cells. P53 was overexpressed in ten cases (47.62%). Six cases (28.57%) had EBV infection, with EBNA1 and EBERs expression, but not LMP1.There were no significant differences in morphology and immunophenotype between EBV-positive and EBV-negative cases. Conclusions: sBL is uncommon in Guangzhou district, mainly seen in boys and young men. Most patients had lymph node (s) involvement, showing similar morphology and immunophenotype as that of endemic BL. Type I EBV latent infection is associated with 28.57% of cases.
