Value of Tumor Markers in Diagnosing and Monitoring Colorectal Cancer and Strategies for Further Improvement:Analysis of 130 Cases
10.3321/j.issn:1000-467x.2007.11.013
- VernacularTitle:肿瘤标志物在结直肠癌诊断和监测中的价值和改进策略:130例患者的临床资料分析
- Author:
Chuang CHEN
1
;
Li-Qin CHEN
;
Guo-Liang YANG
;
Yan LI
Author Information
1. 武汉大学附属中南医院
- Keywords:
Colorectal neoplasm;
Tumor markers;
Clinical staging;
Early diagnosis;
Protein biochip
- From:Chinese Journal of Cancer
2007;26(11):1221-1226
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND & OBJECTIVE: Measurement of blood tumor markers is the most widely used and convenient method for the diagnosis of colorectal cancer(CRC). This study was to evaluate the diagnostic value of a biochip diagnostic system C12 in the diagnosis of CRC. METHODS: Twelve tumor markers were detected in the sera of 130 pathologically confirmed CRC patients, including carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 242 (CA242), cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), prostate specific antigen (PSA), free-PSA (f-PSA) , neuron-specific enolase (NSE), human chorionic gonagotropin-beta (B-HCG), human growth hormone (HGH), and ferritin, using the C12 diagnostic biochip system. The most relevant tumor markers and the most useful combinations of tumor markers were determined. RESULTS; The overall diagnostic rate for the 130 patients was 42.3%; and the diagnostic rates were 13.6%, 39.5%, 38.2% and 68.8%, for stages Ⅰ , Ⅱ , Ⅰ and IV patients, respectively. There was significant difference in the diagnostic rates between stage Ⅰ and stage IV patients. Among all the 12 markers, CEA had the highest diagnostic rate of 35.4%. Any combinations of the 5 most relevant tumor markers did not significantly improve the diagnostic rate. However, the combination of 4 markers (CEA+f-PSA + CA125+CA242 or CEA+CA19-9+CA125+f-PSA) was as good as 12 markers in terms of diagnosis. CONCLUSIONS; The C12 biochip diagnostic system has some value in the diagnosis of advanced CRC, but its sensitivity for the diagnosis of early CRC is not satisfactory.
