Analysis of the epidemic characteristics and disease burden of hospitalized children with viral myocarditis in China from 2016 to 2021
10.3760/cma.j.cn112866-20240219-00020
- VernacularTitle:2016—2021年我国儿童病毒性心肌炎流行特征及疾病负担分析
- Author:
Luci HUANG
1
;
Wei SHAO
;
Lingyun GUO
;
Yiliang FU
;
Fei LI
;
Hui XU
;
Guoshuang FENG
;
Lu GAO
;
Zhengde XIE
;
Yue YUAN
;
Gang LIU
;
Xiangpeng CHEN
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院 北京市儿科研究所感染与病毒研究室 儿科重大疾病研究教育部重点实验室 国家呼吸系统疾病临床医学研究中心 儿童呼吸道感染性疾病研究北京重点实验室 中国医学科学院儿童危重感染诊治创新单元，北京 100045
- Keywords:
Viral myocarditis;
Children;
Epidemiology;
Disease burden
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(4):432-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to provide basic data for the prevention, diagnosis and treatment of pediatric viral myocarditis (VMC) in China through analyzing the epidemic characteristics and disease burden of pediatric inpatients with VMC from 2016 to 2021.Methods:We performed a descriptive statistical analysis to the age, genders, seasons, regions and hospitalization cost and days of pediatric VMC inpatients and the death. All of the information was obtained from 27 Children′s hospitals or Maternal and Child Health hospitals of 23 provinces of China from 2016 to 2021.Results:A total of 7 647 599 cases including 1 646 VMC inpatients were admitted into our study. The annual numbers of hospitalizations were 173, 227, 313, 301, 295 and 337, with the hospitalized constituent ratios being 14.9/100 000, 17.9/100 000, 23.0/100 000, 20.5/100 000, 26.5/100 000 and 26.4/100 000 from 2016 to 2021. In recent 6 years, the proportion of VMC hospitalizations had increased yearly ( P<0.001), and had associated with the onset age ( P<0.001). Aged 12-≤18 years owned the highest hospitalized constituent ratio. The Northeast of China owned the largest number of VMC inpatients, and the East second to it. Among the 1 646 VMC children, there were 68 deaths, with the hospitalized case fatality rate of 4.13%. There were no significant differences between genders, age, seasons, years and fatality rate of VMC inpatients. For the diseases burden, the median of hospitalization days of all VMC inpatients was 10 days (IQR 6, 21), and the median of hospitalization cost was 1 1 842.3 RMB (IQR 6 969.22, 19 714.78). The median of hospitalization days of deceased VMC children was only 1 day (IQR 1, 3), the median cost could be 8 874.03 RMB (IQR 5 277.94, 5 6 151.59). Conclusions:In this study, we found that proportion of hospitalization of VMC children increased year by year, adolescence might be a risk factor of VMC. The fatality of VMC inpatients could be up to 4.13%, and the death led to a huge economic burden of society, family and individuals.
