Detection of serum food specific antibodies of 6 common foods in patients with IgA nephropathy
10.3969/j.issn.1673-4254.2014.03.27
- VernacularTitle:IgA肾病患者血清6种常见过敏食物特异性抗体的检测
- Author:
Chaomin ZHOU
1
;
Zhigang LIU
;
Weiguo SUI
;
Dongfeng GU
;
Yongqiang LI
;
Hequn ZOU
Author Information
1. 南方医科大学第三附属医院肾内科 泌尿疾病研究所
- Keywords:
IgA nephropathy;
food antigen;
allergens;
ELISA
- From:
Journal of Southern Medical University
2014;(3):419-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy. Methods A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire. Results Serum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05). There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria. Conclusion Some foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.
