Donations after cardiac death kidney transplantation in northwest China
10.3969/j.issn.1673-4254.2014.03.26
- VernacularTitle:西北地区开展公民心脏死亡后捐献肾脏移植的报告
- Author:
Xiaoming PAN
1
;
Wujun XUE
;
Linjuan LIU
;
Heli XIANG
;
Chenguang DING
;
Shuqin HE
;
Li REN
;
Puxun TIAN
;
Xiaom-Ing DING
Author Information
1. 西安交通大学医学院第一附属医院肾病中心
- Keywords:
donation;
cardiac death;
kidney transplantation;
outcome;
delayed graft function;
complication
- From:
Journal of Southern Medical University
2014;(3):414-418,433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of donations after cardiac death (DCD) kidney transplant performed in northwest China and the measures for management of delayed graft function (DGF). Methods In the period of 2011-2013, a total of 51 families of DCD donor gave their consent to organ donation by signing the informed consent with the help by a Red Cross Organization (ROC) coordinater, and 102 kidneys were retrieved by organ procurement organization (OPO) teams. Ninety-four operations of renal transplantation were carried out in our hospital. All the patients were followed-up and based on the occurrence of DGF after transplantation, they were divided into DGF group and non-DGF group for comparative studies. Results The success rate of donation after cardiac death was 29.3%, and the incidence of post-transplantation DGF was 27.7%. The 1-year human/kidney survival rate was 98.9%/95.7%. Within six months after the transplant, the values of eGFR in DGF group were significantly lower and serum creatinine significantly higher than those in non-DGF group (P<0.05), but no significant differences were found between the two groups thereafter (P>0.05). The occurrence of DGF in LifePort mechanical perfusion cohorts was significantly lower than that in the simple cold preservation group (21.5% vs. 41.4%, P<0.05). Conclusion The overall effect of DCD kidney transplant is good despite a high incidence of early DGF, and we recommend the use of low-temperature mechanical perfusion for storage and transportation of DCD donor kidney.
