Epstein-Barr Virus Serology in Early Detection and Screening of Nasopharyngeal Carcinoma
10.3321/j.issn:1000-467X.2006.02.025
- VernacularTitle:早期发现和筛选鼻咽癌的EB病毒血清学检测
- Author:
Mun-Hon NG
1
;
Kwok-Hung CHAN
;
Sze-Park NG
;
Yong-Sheng ZONG
Author Information
1. Faculty of Medicine,Hong Kong University
- Keywords:
Nasopharyngeal neoplasms/etiology;
Epstein-Barr virus;
Serologic detection
- From:Chinese Journal of Cancer
2006;25(2):250-256
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma (NPC) is a common canceramong Chinese, especially Southern Chinese; except for a few other ethnic groups with moderate incidence, it is otherwise a rare cancer in the world.NPC has a male dominance of about 3:1 and mainly afflicts people in midlife. There is now compelling evidences to suggest that Epstein-Barr virus (EBV), a category Ⅰ human tumor virus defined by UICC (International Agency for Research on Cancer) in 1997, is a causal agent of NPC and is most likely to be involved in the multi-step and multi-factorial development of NPC. In this article, the role of EBV in pathogenesis of NPC is reviewed briefly, and principle applications of EBV antibodies and EBV DNA as markers of NPC are outlined. Based on current knowledge of EBV antibody responses by NPC and taking available testing technologies into account,serologic screening strategy to facilitate efficient early detection of NPC is formulated.
