Mechanisms of neutrophil-mediated injury to respiratory tract by adenovirus infection
10.3760/cma.j.cn112866-20240222-00023
- VernacularTitle:中性粒细胞在呼吸道腺病毒感染中的免疫损伤机制
- Author:
Shiyuan FAN
1
;
Saizhen ZENG
Author Information
1. 湖南师范大学附属第一医院（湖南省人民医院），长沙 410005
- Keywords:
Human adenovirus;
Neutrophils;
Immune injury
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(3):357-363
- CountryChina
- Language:Chinese
-
Abstract:
Human adenovirus (HAdV) is a common pathogen causing respiratory tract infections. Severe cases of HAdV infection clinically present as critical illness, with a potentially high mortality rate, and may also result in the sequelae of obstructive bronchiolitis, closely intertwined with the mechanism of immune injuries. Neutrophil infiltration plays a crucial role in the early inflammatory response. However, it is a double-edged sword as it plays the role of a " protector" for the body. When it is excessively activated, it can trigger respiratory bursts, degranulation, and other cell signaling pathway dysregulation, causing acute or chronic inflammatory damage to local tissues or even the whole body system. This review aims to elucidate the mechanisms of neutrophil-mediated damage to respiratory tract infections caused by HAdV, providing a reference for early clinical intervention and medication, in order to maximize the benefits and reduce complications for critically ill patients in the early stages of the disease.
