Therapeutic effect of levetiracetam add-on treatment for frontal lobe epilepsy in 105 children
10.3969/j.issn.1673-4254.2014.03.15
- VernacularTitle:左乙拉西坦添加治疗小儿额叶癫痫：附105例报告
- Author:
Yuxin ZHANG
1
;
Qiongxiang ZHAI
;
Zhihong TANG
;
Muqing ZHUO
Author Information
1. 广东省人民医院儿科//广东省医学科学院//广东省神经科学研究所
- Keywords:
frontal lobe epilepsy;
levetiracetam;
electroencephalogram;
seizure attacks;
add-on therapy
- From:
Journal of Southern Medical University
2014;(3):364-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes in 24- hour video electroencephalogram (EEG) and epileptic attacks after levetiracetam add-on therapy in children with frontal lobe epilepsy and epileptiform discharges. Methods A prospective study was carried out in 105 children with the frontal lobe epilepsy who received long-term treatment with 1 or 2 types of antiepileptic drug but still with epileptiform discharges in ECG. Levetiracetam add-on therapy was administered at the initial daily dose of 20 mg/kg (given in 2 doses) for 2 weeks followed by an increase of the dose to 30 mg/kg with a maintenance dose of 30-40 mg/kg. The changes in seizure attacks and 24-hour video-EEG monitoring after a 6-month therapy were observed. Results Levetiracetam add-on therapy reduced epileptiform discharges in 55 children (52.3%) and resulted in significant changes in EEG (P<0.05). Of the 77 children with clinical seizures, complete seizure control was achieved in 12 cases after the therapy, and the seizure attacks were reduced in 28 cases, showing a total response rate of 51.9%; the reduction in seizure attacks was positively correlated with EEG improvement (P<0.001). Conclusion Levetiracetam add-on therapy can decrease epileptiform discharges in EEG and reduce clinical seizure attacks in children with frontal lobe epilepsy with only mild adverse reactions.
