Relationship between Vitamin D Level and Survival in Terminally Ill Cancer Patients.
10.14475/kjhpc.2015.18.2.120
- Author:
Sun Young CHOI
1
;
Youn Seon CHOI
;
In Cheol HWANG
;
June Young LEE
Author Information
1. Department of Family Medicine, Catholic Kwandong University College of Medicine, International ST. Mary's Hospital, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Vitamin D;
Terminal care;
Survival analysis;
Hospices
- MeSH:
Hospices;
Humans;
Hyperbilirubinemia;
Logistic Models;
Retrospective Studies;
Survival Analysis;
Terminal Care;
Terminally Ill*;
Vitamin D Deficiency;
Vitamin D*
- From:Korean Journal of Hospice and Palliative Care
2015;18(2):120-127
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We aimed to investigate how serum vitamin D levels are related to survival of terminally ill cancer patients. METHODS: From May 2012 through June 2013, a retrospective chart review was performed on 96 hospice patients. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with severe vitamin D deficiency and Coxcy and Coxional hazard analyses were used to evaluate effects on survival. RESULTS: The mean vitamin D level in patients was 8.60+/-7.16 ng/ml. Vitamin D was severely deficient (<10 ng/ml) in 75 patients (78.2%), deficient (10~20 ng/ml) in 13 patients (13.5%), relatively insufficient (21~29 ng/ml) in five patients (8.3%) and sufficient ((t ng/ml) in three patients (3.1%). Hyperbilirubinemia (> or =1.2 g/dl) was the only factor associated with severe vitamin D deficiency according to the multiple logistic regression analysis (Odds ratio, OR=18.48, P<0.05). Although hyperbilirubinemia showed a strong association with survival (Hazard ratio, HR=2.25, P<0.01), no association was found between severe vitamin D deficiency and survival (HR=1.15, P>0.05) in Cox's proportional hazard analysis. CONCLUSION: Although serum vitamin D levels were severely low in terminally ill cancer patients, we found no association between severe vitamin D deficiency and patient survival.
