Radiation Induced Temporomandibular Joint Lesion in Patients with Nasopharyngeal Carcinoma
10.3321/j.issn:1000-467X.2001.06.022
- VernacularTitle:鼻咽癌患者放疗后张口困难及其影响因素
- Author:
Ming CHEN
1
;
Xiang-Fa ZENG
;
Chong ZHAO
;
Shao-Xiong WU
;
Xiao-Yan HUANG
;
Fei HAN
;
Wei LUO
;
Tai-Xiang LU
;
Nian-Ji CUI
Author Information
1. Sun Yat sen University of Medical Sciences
- From:Chinese Journal of Cancer
2001;20(6):651-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective：The aim of this study was to evaluate radiation induced temporomandibular joint damage in the patients with nasopharyngeal carcinoma, and its correlative factors were analyzed. Methods： From November 7, 1966 to July 2, 1999, 352 patients with nasopharyngeal carcinoma received radical conventional radiotherapy were eligible for this analysis. The total dose of the temporomandibular joint were 51.90－ 78.89 gray and the overall treatment time were 35－ 141 days. The endpoint was the distance between two dens incisivus medialis (DDIM). The relationship between total doses and temporomandibular joint lesion was illustrated with curve estimation. Multivariate analysis with Logistic Regress was performed to evaluate the significance of prognostic variables on temporomandibular joint lesion. Results： The patient of DDIM60.00－ 70.00 gray, and >70.00－ 78.89 gray were 46.4％ , 53.5％ , and 62.3％ , respectively (P=0.050); and in the patients who insisted in opening mouths practice or not were 51.6％ and 61.7％ respectively (P=0.028); and in patients at age of 18－ 42 and 43－ 71 were 54.1％ and 62.7％ respectively(P=0.040). They were all significant prognostic factors for radiation induced temporomandibular joint lesion. Conclusion： Radiation induced temporomandibular joint lesion in radiation treated NPC patients was serious. The total dose of temporomandibular joint, opening mouths practice and age are three significant prognostic factors.
