Association of leptin receptor gene polymorphisms with hypertension in Chinese population:a meta-analysis
- VernacularTitle:瘦素受体基因多态性与中国人群高血压相关性的meta分析
- Author:
Nan JIN
1
;
Ge LI
;
Hui LI
;
Fan ZHANG
;
Ling CHEN
;
Bing LENG
Author Information
1. 重庆医科大学公共卫生与管理学院流行病学教研室
- Keywords:
hypertension;
leptin receptor;
gene polymorphism;
meta-analysis
- From:
Journal of Southern Medical University
2014;(2):265-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese population. Methods The keywords"Hypertension","Blood Pressure, high","Leptin Receptor","OB Receptor","LEPR Protein","CD295 Antigens", and "LEPR" were used to search the literature to identify the relevant studies for meta-analysis using software RevMan 5.0 and Stata 11.0 software. Results Thirteen studies involving 3210 cases of hypertension and 1881 controls were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and hypertension in allele contrast and dominant genetic model (for allele contrast genetic model: OR=1.17, 95%CI=1.48-2.15, P<0.0001;for dominant model:OR=2.18, 95%CI=1.75-2.72, P<0.00001). No statistically significant correlation was found between Lys109Arg polymorphism and hypertension (for allele model:OR=1.13, 95%CI=0.84-1.51, P=0.42;for recessive genetic model:OR=0.88, 95%CI=0.33-2.32, P=0.79;for dominant genetic model:OR=1.20, 95%CI=0.85-1.71, P=0.29;for additive genetic model:OR=0.90, 95%CI=0.34-2.42, P=0.84). Conclusion There is no significant correlation between Lys109Arg variant of LEPR gene and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast and dominant genetic model. Chinese population with an A allele are at a high risk of developing hypertension.
