Clinical Applications of Magnetic Resonance Imaging for Patients with Bone Marrow Diseases
10.3321/j.issn:1000-467X.2001.06.018
- VernacularTitle:骨髓异常的磁共振成像及其临床应用研究
- Author:
Jun SHEN
1
;
Ling Bi LIANG
;
Yu Jian CHEN
Author Information
1. Sun Yat sen Memorial Hospital Sun Yat sen University of Medical Sciences
- From:Chinese Journal of Cancer
2001;20(6):638-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective：This study was designed to evaluate the clinical application of magnetic resonance imaging (MRI) in the patients with bone marrow diseases. Methods： A total of 78 normal persons and 44 patients with bone marrow diseases including 15 with leukemia, 13 with non Hodgikin s lymphoma, 16 with hyperplastic anemia were examined with spinal MRI and bone marrow aspirations and peripheral blood tests. MR imagings and clinical data were qualitatively and quantitatively analyzed, meanwhile, quantitative MRI information was correlated with clinical experimental parameters. All the diagnosis had been pathologically proven by bone marrow aspiration or/and biopsy. Results： ① On T1 weighted imaging(T1WI), leukemia group and lymphoma group showed more hypo intensity signals than hyperplastic anemia group and normal group (P< 0.05). On T2 weighed imaging (T2WI), more hyper intensity showed in the two former than in hyperplastic anemia and normal group (P< 0.05). After injection of contrast material, normal group, leukemia group, and lymphoma group had not manifested different degree of enhancement (P >0.05). Diffuse signal changes occurred more often in leukemia group than in lymphoma group (P=0.000). ② On T1 weighted imaging, the signal intensity ratio of marrow to muscle(SIR1) in leukemia group and lymphoma group were lower than that in normal group and hyperplastic anemia group (P< 0.05). ③ SIR1 of hyperplastic anemia was correlated positively with myelocyte erythroblast ratio(P=0.006), negatively with the percentage of erythrocyte in bone marrow (P=0.008), SIR1 of leukemia was correlated negatively with the percentage of premature cell in bone marrow (P=0.048). Conclusions： MRI can directly reveal the distribution of red marrow in spine. Malignant and benign marrow processes can be differentiated on MRI with qualitative analysis; The usefulness of quantitative analysis of SIR1 is limited, but it could be used to roughly evaluate the severity of hyperplastic anemia and tumor burden of leukemia.
