Expression of p21waf1, c erbB 2, and p53 Genes in Node Negative Breast Carcinoma and Their Clinical Significance

Wei DU; Guang Can ZENG; Hua Tie RONG; Hui Jing HOU

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Expression of p21waf1, c erbB 2, and p53 Genes in Node Negative Breast Carcinoma and Their Clinical Significance

VernacularTitle:淋巴结阴性乳腺癌p21waf1、c-erbB-2和p53蛋白表达及其临床意义
Author: Wei DU ¹ ; Guang Can ZENG ; Hua Tie RONG ; Hui Jing HOU
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1. Sun Yat sen University of Medical Sciences
From:Chinese Journal of Cancer 2001;20(6):631-634
CountryChina
Language:Chinese
Abstract: Objective：The aim of this study was to determine the expression of p21waf1, c erbB 2, and p53 in node negative breast cancer in relation to the clinicopathological parameters and prognosis. Methods： Expression of p21waf1, c erbB 2 and p53 in 121 patients were determined by LSAB immunohistochemical method, and Kaplan Meier method and Cox proportional hazard model were used to analyze the relationship of their expressions with prognosis. Results： (1) The expression rate of p21waf1 was 48.8％ , and was in connection with histological grade and ER positive. (2) The expression rate of p53 and c erbB 2 was 36.4％ and 26.4％ respectively. C erbB 2 positive expression was associated with histological grade. (3) the expression of p21waf1 was inversely correlated with that of p53 protein (P< 0.05). (4) the results of survival analysis with Kaplan Meier method showed that better disease free survival(DFS) in the patients with p21waf1 expression than those without, the negative c erbB 2 expression exhibited a significantly better prognosis than positive c erbB 2 expression (P< 0.01). Conclusions： There was a significant correlation between the expression of p21waf1, c erbB 2,and tumor grade; a p53 indenpent pathway can mainly induce the expression of p21waf1; p21waf1 expression was a good prognostic marker for the patients with node negative breast cancer; c erbB 2 positive expression was an independent prognostic marker.