Immunohistochemical Detection of p53 Protein Alterated Expression in 1 364 Patients with Maligant Tumors and Its Clinicopathological Significance
10.3321/j.issn:1000-467X.2001.06.013
- VernacularTitle:1364例恶性肿瘤p53蛋白表达的检测及其临床病理学意义
- Author:
Xiao-Mei LU
1
;
Zhao-Lun CHEN
;
Bao-Yin SHEN
Author Information
1. Xinjiang Medical University
- From:Chinese Journal of Cancer
2001;20(6):620-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective：The aim of this study was to investigate the effect of p53 gene alterated expression on human carcinogenesis. Methods： p53 protein expression in 1 364 patients with malignant tumors and 628 benign lesions was detected by immunohistochemistry (LSAB). Results： The frenquency of p53 protein positive was significant higher in malignant tumors [56.67％ (733/1364)] than those in related benign lesions [6.7％ (42/623) (P< 0.001)]; It was revealed the similar situation as compared squamous cell cancer (615), adenocarcinoma (382), and other types of malignancies (367) with their related benign lesions respectively (P< 0.001). Conclusion： Alterated expression of p53 protein (gene multation or protein accumulation) may involve one of the critical events of human carcinogenesis. Detection of p53 overexpression may be a useful biomarkers for assessment of maligant tumors.
