Research progress in the changes of viral load and related influencing factors after 2019-nCov infection

VernacularTitle:新冠病毒感染后机体病毒载量变化及相关影响研究进展
Author: Tianmiao BAO ¹ ; Yenan FENG ; Hua FAN ; Cao CHEN
Author Information

1. 山东第一医科大学公共卫生与健康管理学院，济南　250117
Keywords: Coronavirus disease 2019; 2019-nCoV; Viral load; Viral replication; Immune clearance
From: Chinese Journal of Experimental and Clinical Virology 2024;38(1):99-104
CountryChina
Language:Chinese
Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a novel Coronavirus, 2019-nCov. As of December 24th, 2022, the COVID-19 pandemic has spread to over 220 countries and regions, with a total of more than 770 million confirmed cases and 6.6 million deaths. The pandemic has had a profound impact on the global economy, political landscapes and daily life. The 2019-nCoV undergoes continues mutation, with variants exhibiting increased transmissibility triggering multiple waves of outbreaks worldwide. Once inside the human body, the 2019-nCoV replicates, and its viral load undergoes continuous fluctuations. The comprehension of virus clearance patterns can help epidemic prevention and control and disease diagnosis and treatment. This paper presents an overview of research advancements in the changes following infection with 2019-nCoV, from the perspectives of viral replication and immune clearance.