Evidence of Genetic Instabilities on Chromosome 16q22 24 in Nasopharyngeal Carcinoma

VernacularTitle:鼻咽癌染色体16q22-24遗传不稳定性的研究
Author: Jian YAN ¹ ; Yan FANG ; Jun Bi HUANG ; Wan Qi LIANG ; Xin Yi ZENG
Author Information

1. Sun Yat sen University of Medical Sciences
From:Chinese Journal of Cancer 2001;20(6):588-590
CountryChina
Language:Chinese
Abstract: Objective：This study was designed to evaluate the genetic stability on chromosome 16q22 24 in primary nasopharyngeal carcinoma. Methods: Tissue samples from fifty patients with nasopharyngeal carcinoma (NPC) tumors were examined by loss of heterozygosity (LOH) and microsatellite instability (MSI) analysis with a panel of 8 microsatellite polymorphic markers distributed along the chromosome 16q22 24. Results: LOH was observed at one or more loci in 24 cases (48％ ) and the prevalence of MSI was detected in 9 cases (18％ ). But the genomic alterations scattered along the region, neither common deletion or instability region was found. Conclusions: The status of genetic stability in chromosome 16q22 24 suggests that the genomic alterations on chromosome 16q22 24 may be involved in the development of NPC.