Effect of differences in health care situations on the survival of patients with sporadic Creutzfeldt-Jakob disease
10.3760/cma.j.cn112866-20231027-00046
- VernacularTitle:医护情况差异对散发型克-雅病患者生存期影响的研究
- Author:
Weiwei ZHANG
1
;
Donghua ZHOU
;
Yuan WANG
;
Kang XIAO
;
Donglin LIANG
;
Wei ZHOU
;
Xiaoping DONG
;
Qi SHI
Author Information
1. 华北理工大学公共卫生学院，唐山 063210
- Keywords:
Sporadic Creutzfeldt-Jakob disease;
Healthcare situation;
Survival time;
COX proportional risk regression modeling
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(1):37-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the medical care of patients with sporadic Creutzfeldt-Jakob disease in China and its relationship with survival time.Methods:A retrospective analysis was performed on data of 150 patients with sporadic Creutzfeldt-Jakob disease diagnosed by China′s Creutzfeldt-Jakob Disease Surveillance Network during the period of January 1, 2021 to December 31, 2022 in this study, and telephone follow-up with family members was used to obtain information of the patients′ care, treatment, and survival after diagnosis. Survival was estimated by life table method, median survival time and 95% confidence interval ( CI) were calculated by Kaplan-Meier method, log-rank method was used to compare the difference in survival time between different groups, and multifactorial analysis was performed by COX proportional risk regression model regarding the influencing factors on patients′ survival time. Results:The median survival time of 150 patients with sporadic Creutzfeldt-Jakob disease was 6 months, and the cumulative lifetime survival rates at 2, 6, 12, and 18 months were 62%, 39%, 22%, and 9%, respectively. The result of univariate analysis showed that the differences in survival time between groups with the presence or absence of cortical blindness in the first symptom, the presence or absence of respiratory support (oxygen therapy), the presence or absence of adjunctive medication, and the presence or absence of tube feeding (nasogastric) were meaningful ( P<0.1). Multifactorial COX regression analysis showed that the risk of death in patients without adjuvant medication was 1.429 times higher than that in patients with adjuvant medication (95.0% CI: 1.014-2.014), and the risk of death in patients without tube feeding (nasal feeding) was 1.479 times higher than that in patients with tube feeding (nasal feeding) (95% CI: 1.052-2.081). Conclusions:Whether or not adjuvant medication is administered and whether or not tube feeding (nasogastric) is used are factors that affect survival time in patients with sporadic Creutzfeldt-Jakob disease, and the administration of appropriate adjuvant medication and tube feeding (nasogastric) may contribute to prolonging survival time in patients with sporadic Creutzfeldt-Jakob disease.
