Expression and Prognostic Values of p21 Protein and Estrogen Receptor in Colorectal Cancers
10.3321/j.issn:1000-467X.2001.05.020
- VernacularTitle:大肠癌 p21蛋白和雌激素受体表达 与预后的关系
- Author:
Zi-Ke QIN
1
;
De-Sen WAN
;
Han-Liang LIN
;
Jing-Hui HOU
;
Jun-Yan LIAN
Author Information
1. Sun Yat-sen University of Medical Sciences
- From:Chinese Journal of Cancer
2001;20(5):531-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective： This study was designed to explore the relationship between clinicobiological acting and expression of p21 protein and estrogen receptor(ER) in colorectal cancer. Methods： The intensity of expression of p21 protein and ER for 206 patients with colorectal cancers were determined by labeled-streptokinase avidin-biotin(LSAB) assay. Results： The expression of p21 protein is negatively correlated with that of ER in colorectal cancer(r=-0.6613, P<0.01). The intensity of expression of p21 protein and ER in colorectal cancers were not related with the patients age, sexuality, tumor position, pathological type, histological type, Dukes stage etc.(r< 0.4,P>0.05). Both the expressions were related to the prognosis of colorectal cancer(P<0.01). Higher the intensity of expression of p21 protein worse the patients prognosis, and higher the intensity of expression of ER better the patient s prognosis. Conclusions： The abnormal expression of p21 protein is related to the dysbolism of estrogen in colorectal cancer. The detection of p21 protein and ER are helpful for diagnosis and prognostic evaluation for colorectal cancer.
