Recent advancements in human papillomavirus detection methodology
10.3760/cma.j.cn112866-20230916-00029
- VernacularTitle:人乳头瘤病毒检测方法最新进展
- Author:
Cheng SONG
1
;
Shaokai ZHANG
;
Youlin QIAO
Author Information
1. 中国医学科学院北京协和医学院群医学及公共卫生学院全球健康中心，北京 100005
- Keywords:
Human papillomavirus;
HPV testing;
Target amplification
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(6):670-675
- CountryChina
- Language:Chinese
-
Abstract:
Human papillomavirus (HPV) is the most common sexually transmitted virus, of which high-risk HPV mainly infects mucosal epithelial cells causing malignant transformation of the cells. HPV infection could ultimately develop to malignant tumors including cervical, head and neck, anal, penile, vulvar, and vaginal cancers. The burden of cervical cancer is highest among these cancers and high-risk HPV persistent infection is considered an etiologic factor in its development. Therefore, it is crucial to identify early infected cases and determine HPV infection status by HPV testing. HPV testing can also be used for prophylactic HPV vaccine efficacy assessment, triage of women with cytological abnormalities, prediction of post-treatment efficacy and identification of HPV-attributable malignant lesions. There is the scarcity of studies elucidating the existing HPV detection methodologies. Through providing a comprehensive landscape of the currently available HPV detection methodologies, including their principles, applications, and clinical use, the ultimate objective is to provide information for the clinical practice of HPV detection, so as to reduce the incidence and mortality rates of HPV-associated diseases.
