CXCR4 and Nrf2 expressions in non-small cell lung cancer and their clinical implications
- VernacularTitle:非小细胞肺癌组织中CXCR4和Nrf2的表达及其临床意义
- Author:
Tinghua HU
1
;
Yu YAO
;
Shuo YU
;
Hui GUO
;
Tao TIAN
;
Lili HAN
;
Wenjuan WANG
;
Qianqian GUO
;
Jing WANG
;
Kejun NAN
;
Shuhong WANG
Author Information
1. 西安交通大学医学院第一附属医院呼吸内科
- Keywords:
CXCR4;
Nrf2;
non-small cell lung cancer;
biomarker
- From:
Journal of Southern Medical University
2014;(2):153-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of CXCR4 and Nrf2 in non-small cell lung cancer (NSCLC) tissues and analyze their association with the clinicopathological features of NSCLC. Methods We investigated the expressions of CXCR4 and Nrf2 in 66 NSCLC and corresponding distant normal tissue specimens using immumohistochemistry and real-time PCR. Results The expressions of CXCR4 protein and mRNA were significantly higher in NSCLC tissue specimens than in the distant normal tissues, while the expression of Nrf2 protein and mRNA increased significantly in NSCLC tissues compared to those in the distant normal tissues (P<0.01). A high expression level of CXCR4 was positively correlated with a large tumor size (P=0.048), poor differentiation (P=0.024), advanced TNM stage (P=0.018), lymph node metastasis (P=0.004), and distant metastasis (P=0.016). The expression of Nrf2 protein was positively correlated with a large tumor size (P=0.008), advanced TNM stage (P=0.028), lymph node metastasis (P=0.038), and distant metastasis (P=0.023). A strong correlation was found between CXCR4 and Nrf2 expressions in NSCLC tissues (r=0.324, P<0.01), and the co-expression of CXCR4 and Nrf2 was strongly correlated with lymph node metastasis and distant metastasis. Conclusion Abnormal expressions of CXCR4 and Nrf2 may contribute to the progression and malignant biological behavior of NSCLC.
