Pro-apoptosis and selective anticancer activities of prostate apoptosis response protein 4:re-search progress and prospects
- VernacularTitle:前列腺凋亡应答蛋白4促凋亡和肿瘤特异性抑制作用的研究进展
- Author:
Zengding WU
1
;
Guanlin WANG
;
Kuanren ZHANG
Author Information
1. 昆明理工大学生命科学与技术学院分子药理组
- Keywords:
prostate apoptosis response protein 4;
SAC;
apoptosis;
anti-cancer
- From:
Journal of Southern Medical University
2014;(1):128-132
- CountryChina
- Language:Chinese
-
Abstract:
As a pro-apoptotic factor, prostate apoptosis response protein 4 (par-4) was first found in the male hormone-dependent prostate cells (AT-3). Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4 selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In this review we summarize the discovery, structure, and function of par-4, and its intracellular signaling pathways, then discuss the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical applications.
