Inhibitory Effect of As2O3 on Nude Mice Ascitis Production Planted by Gastric Cancer Cell Line
10.3321/j.issn:1000-467X.2001.05.006
- VernacularTitle:三氧化二砷对人胃癌裸鼠腹腔种植 腹水生成的影响
- Author:
Xing-Rong ZHANG
1
;
Hong-Pei CAI
;
Zhi-Hua DENG
;
Jian-Wei SHEN
Author Information
1. Changzheng Hospital the Second Military Medical University
- From:Chinese Journal of Cancer
2001;20(5):477-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The aim of this study was to observe the effect of As2O3 on malignant ascites of nude mice and investigate its mechanism. Method： One hundred BALB/c-nu/nu nude mice were injected with MKN-45 gastric cancer cell line and were divided into 5 groups at random： Group 1, normal saline; Group 2, Epirubicin; Group 3-5, various concentration of As2O3. The rate of tumor formation, production of ascites and survival period were evaluated. Morphological changes of tumor cell were observed with electromicroscope. Result： Epirubicin and low dose of As2O3 obviously inhibited the production of ascites and prolonged the survival period of tumor-loading nude mice （ P<0.01). Mid to high doses of As2O3 eradicated cancer cells through the way of apoptosis. Conclusion： As2O3 could induce gastric cancer cell apoptosis, inhibit or eradicate production of ascites and prolong the survival period of nude mice that suffered from malignant ascites from metastasis
