xpression of Novel Immunoglobulin Gene SNC73 in Colorectal Cancer by In Situ Hybridization
10.3321/j.issn:1000-467X.2001.05.002
- VernacularTitle:原位杂交检测新免疫球蛋白基因 SNC73 在大肠癌中的表达
- Author:
Feng YE
1
;
Shu ZHENG
;
Shi-Chang FANG
;
Jia-Ping PENG
;
Qi DONG
;
Li-Yi GENG
;
Jiang CAO
Author Information
1. 浙江大学
- From:Chinese Journal of Cancer
2001;20(5):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objectives： This study was designed to observe the histological localization of SNC73 gene expression in colorectal cancer, and to investigate their expression in different phases from normal epithelium, transitional mucosa, adenoma to carcinoma, and to discuss the relationship between SNC73 gene expression and the clinic factors of colorectal cancer. Method： With in situ hybridization, the expression of the SNC73 was determined in 29 patients with colorectal cancer group specimens as the above. Results： SNC73 gene expression was observed in normal mucosal tissue and some lymph follicles of the mucosa, but seldom in cancer tissue. The positive rate of SNC73 expression was 20.69％ in colorectal cancer; was 62.07％ in normal mucosa; was 31.03％ in adjacent tissue; and was 20.00％ in adenoma. Statistical difference was found between expressions in normal mucosa and those in colorectal carcinoma from the same patient (P<0.01). Conclusions： The positive rate of SNC73 expression in colorectal cancer is lower than that in corresponding normal mucosa. The biological function of SNC73 may be different from that of common immunoglobulins.
