Research progress in structure and function of human parainfluenza virus encoded proteins
10.3760/cma.j.cn112866-20230816-00018
- VernacularTitle:人副流感病毒编码蛋白的结构及其功能研究进展
- Author:
Yi FENG
1
;
Jie JIANG
;
Yixuan GAO
;
Zhen ZHU
;
Naiying MAO
Author Information
1. 中国疾病预防控制中心病毒病预防控制所麻疹室 世界卫生组织西太平洋地区麻疹/风疹参比实验室 国家卫生健康委员会医学病毒和病毒病重点实验室，北京 102206
- Keywords:
Human parainfluenza virus;
Structural protein;
Protein function
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(5):548-557
- CountryChina
- Language:Chinese
-
Abstract:
Human parainfluenza viruses (HPIVs) comprise four serotypes (HPIV1-4) and are the second most common pathogens responsible for severe acute respiratory tract infections in infants worldwide. Additionally, HPIVs play a significant role as etiological agents of lower respiratory tract infections in organ transplant recipients, immunocompromised individuals, patients with chronic diseases, and the elderly. HPIVs belong to the Paramyxoviridae family. Among them, HPIV1 and HPIV3 belong to the genus Respirovirus, while HPIV2 and HPIV4 belong to the genus Rubulavirus. The viral genome of HPIV1-4 is approximately 15-17 kb in length and encodes six major structural proteins, including the nucleocapsid protein, phosphoprotein, matrix protein, fusion protein, hemagglutinin-neuraminidase protein, and large RNA-dependent RNA polymerase. In addition, different serotypes of HPIVs also encode several small proteins involved in viral replication. This review summarizes current research advances in the structure and function of genome-encoded proteins, regulatory mechanisms of viral genome transcription and replication, and interactions with host cells to deepen the understanding of the function of HPIVs genome-encoded proteins.
