Bronchial Arterial Infusion of Chemotherapeutic Drugs in Treatment of Patients with Locally Advanced Non-Small Cell Lung Cancer
10.3321/j.issn:1000-467X.2001.04.020
- VernacularTitle:支气管动脉灌注化疗药物治疗局部晚期非小细胞肺癌
- Author:
Xiao-Ling CAI
1
;
Xiao-Long CAO
;
Bing-Fen JIANG
;
Tian-Sheng GUO
Author Information
1. People s Hospital of Panyu
- From:Chinese Journal of Cancer
2001;20(4):423-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This study was designed to evaluate the therapeutic efficacy of bronchial arterial infusion with VDS＋ DDP or MMIC＋ ADM＋ DDP in patients with locally advanced nonsmall cell lung cancer(NSCLC). Methods: From June 1992 to October 1998,102 patients with locally advanced NSCLC were enrolled in this study. Of them,8 cases in Stage Ⅱ , 72 cases in Stage Ⅲ a, 22 cases in Stage Ⅲ b, central type: 75 cases,peripheral type:27 cases;preliminary group 64 cases, secondary group 38cases. The patients were treated one to four times by bronchial arterial infusion of the chemical drugs Results: There were 3 complete responses and 66 partial responses for an overall responses rate of 67.65％ (69/102) including responses rate of 72.00％ (54/75) in central type and 55.56％ (15/27), the 1-year and 2-years survival rate was 67.64％ (69/102)and 36.28％ (37/102) respectively. Conclusions: The therapeutic efficacy of bronchial arterial infusion with chemical drugs was excellent to locally advanced non small cell lung cancer, it′ s toxicity were acceptable. The efficacy on central was much better than for peripheral type
