Concomitant Cisplatin and 5-Fluorouracil with Veinal or with Oral High-Dose Leucovorin in Treatment of Patients with Advanced Nasopharygeal Carcinoma
10.3321/j.issn:1000-467X.2001.04.018
- VernacularTitle:两种不同给药途径的大剂量醛氢叶酸联合5-氟尿嘧啶、顺铂治疗晚期鼻咽癌
- Author:
Ping LI
1
;
Jian ZHENG
;
Liang-Jun GUO
;
Cheng-Hai ZHUANG
Author Information
1. the First Affiliated Hospital Jinan University Medical College
- From:Chinese Journal of Cancer
2001;20(4):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The aim of this study was to assess the efficacy and safety of veinal high dose Leucovorin ＋ 5-FU and cisplatin regimen（PFL1） and oral high dose Leucovorin＋ 5-FU and cisplatin regimen（PFL2） in the treatment of the patients with reccurent nasopharyngeal carcinoma. Methods: From January 1997 to December 1999,53 cases of histologically proven advanced nasopharyngeal carcinoma were unrandomly divided into 2 groups, of whom 28 cases were treated with PFL1 regimen, 25 cases with PFL2 regimen. Results: Complete response rate and respose rates of PFL1 regimen and PFL2 regimen were 17.9％, 64.3％,and 16％, 56％,respectively. All the patients had been followed-up till December 1999. Thirteen patients died and fifteen patients survived and median remission duration was 10.5±5.24 months(range,5-21 months) and median survival duration was 12.5±5.13 months(4-35 month) of PFL1 group. Fourteen patients died and eleven survived and median remission duration was (9.3±3.10) m (4-28 m) and median survival duration was(11.2±3.66) m (4-28 m) of PFL2 group. There was no significant difference in complete response rate, respose rate, median remission duration and median survival duration between the two groups (P>0.05). PFL1 and PFL2 chemotherapy regimens for nasopharyngeal mass, metastasis of neck or abdomen lymphnode, metastasis of lung were effective;for metastasis of bone, the efficacy of releasing pain was good, but the response rate was unsatistactory;for metastasis of liver had no effect. The major toxicity included neucopenia， nausea， vomiting， mucositis et al. （P>0.05）. Vein inflammation had significant differences between two regimens (P<0.05). Alepecia and pigmentation had very significant differences between two regimens (P<0.01). Conclusions: Veinal or oral high dose Leucovorin + 5-Fu+cisplatin were effective combinnation in the chemotherapy of nasopharyngeal carcinoma and the survival duration were longer.
