Evaluation of Four Regimens for Treatment of Patients with Late Nasopharyngeal Carcinoma
10.3321/j.issn:1000-467X.2001.04.017
- VernacularTitle:四种化疗方案治疗晚期鼻咽癌的临床评价
- Author:
Xian-Li YIN
1
;
Jin LI
;
Ping-Hei WANG
Author Information
1. Hunan Tumor Hospital
- From:Chinese Journal of Cancer
2001;20(4):412-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The aim of this study was to evaluate the short-term therapeutic result, toxicity, and side effects of cisplatin＋ 5-fluorouracil (PF) regimen, ADM＋ cisplatin＋ 5-fluorouracil (APF) regimen, IFO＋ cisplatin＋ 5-fluorouracil (IPF) regimen and IFO＋ cisplatin(IP) regimen for the treament of the late, advanced, and recurrent nasopharyngeal carcinoma (LAC-NPC). Methods: Nineteen cases were treated with PF regimen, 22 cases with APF regimen, 30 cases with IP regimen, 26 cases with IPF regimen. The authors summed up the effective rate, the effective rate of the metastasis of carcinoma to lung and the occurrence of leukocytopenia, nausea,vomiting of four kinds of regimen,respectively. The various results of one regimen each of APF,IP,IPF,and PF regimen were statistically analyzed respectively. Results: The result showed that the response rates of PF, APF, IP,and IPF regimen were 42.11％ ,54.55％ ,73.33％ ,76.92％ ,respectively. There was statistical significant difference between one regimen each of IP,IPF,and PF regimen (P<0.05). The effective rate of the metastasis of carcinoma to lung of PF, APF, IP and, IPF regimen were 55.56%, 60%, 88.9%, 88.2, respectively. There was statistical significant difference between IP and PF regimens(P<0.05). Statistical significant difference in the Ⅲ-Ⅳ occurrence of the leukocytopenia was also noted between IP and PF regimen (P<0.05), and between IPF and PF regimens (P<0.01). There was statistical significant difference was noted in occurrence of nausea and vomiting among these four groups (P<0.05). Conclusion: IP and IPF are both effective regimens of chemotherapy for ALC-NPC.
