Changes in peripheral blood monocyte count in children with adenovirus pneumonia and its value in severity assessment
10.3760/cma.j.cn112866-20230529-00056
- VernacularTitle:腺病毒肺炎患儿外周血单核细胞计数变化及其在病情评估中的价值
- Author:
Qing HUANG
1
;
Jialong PAN
;
Dongyun LIN
Author Information
1. 广州医科大学附属第六医院 清远市人民医院儿科，清远 511500
- Keywords:
Adenovirus;
Pneumonia;
Monocyte count;
Children
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(5):491-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes in peripheral blood monocyte count in children with adenovirus pneumonia (AP) and its value in severity assessment.Methods:A retrospective analysis was conducted on the peripheral blood differential leucocyte count of 139 children with AP, and they were compared with 61 healthy children.Results:Compared with the control group, the monocyte count in AP patients was higher ( P<0.001). In the early stage of hospitalization, the monocyte counts in the severe adenovirus pneumonia (SAP) group and the general adenovirus pneumonia (GAP) group were both higher than that in the control group (both P<0.05), while the monocyte count in the SAP group was lower than that in the GAP group ( P<0.05). In the later stage of hospitalization, the monocyte count in the GAP group decreased ( P<0.05), while the monocyte count in the SAP group did not decrease significantly ( P>0.05), and the monocyte count in the SAP group was higher than that in the GAP group ( P<0.05). Multivariate logistic regression analysis showed that a lower monocyte count in the early stage of hospitalization was one of the independent risk factors for SAP ( P=0.004). The area under the receiver operating characteristic (ROC) curve (AUC) of monocyte count in the early stage of hospitalization used for the prediction of SAP was 0.742, with an optimal cutoff value of 1.05×10 9/L, a sensitivity of 74.3% and a specificity of 63.5%. Conclusions:Children with AP may have a varying degree of increase in peripheral blood monocyte count. Compared with children with GAP, children with SAP showed a lower degree of increase in monocyte count, but a slower decrease. Peripheral blood monocyte count can serve as one of the potential indicators for assessing the risk of the progression of AP in children.
