A multicenter study on human parainfluenza virus infections among children with community-acquired pneumonia from 2014 to 2020
10.3760/cma.j.cn112866-20230726-00009
- VernacularTitle:2014—2020年儿童社区获得性肺炎中人副流感病毒感染的多中心研究
- Author:
Shiqi CAI
1
;
Baoping XU
;
Changchong LI
;
Yun SUN
;
Gen LU
;
Rong JIN
;
Yunxiao SHANG
;
Yunlian ZHOU
;
Ling CAO
;
Aihuan CHEN
;
Li DENG
;
Yixiao BAO
;
Limin NING
;
Zhou FU
;
Fang GU
;
Shuilian YU
;
Chunyan LIU
;
Ju YIN
;
Kunling SHEN
;
Yun ZHU
;
Zhengde XIE
Author Information
1. 国家儿童医学中心 国家呼吸系统临床医学研究中心 首都医科大学附属北京儿童医院 儿科重大疾病研究教育部重点实验室 中国医学科学院儿童危重感染诊治创新单元 儿童呼吸道感染性疾病研究北京市重点实验室 北京市儿科研究所 感染与病毒研究室，北京 100045
- Keywords:
Human parainfluenza virus;
Hospitalized children;
Multicenter study;
Molecular epidemiology;
Clinical characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(5):472-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiological and clinical characteristics of human parainfluenza viruses (HPIVs) infection among hospitalized children with community-acquired pneumonia (CAP) in China, and provide basic data for diagnosis, treatment and prevention of HPIVs infection.Methods:From November 2014 to February 2020, 5 448 hospitalized children with CAP were enrolled in 14 hospitals in 11 provinces and municipalities directly under the Central Government in southern China and northern China. Nasopharyngeal aspirates or throat swabs were collected, and the nucleic acids of 18 types respiratory viruses including HPIV1-4 were screened by suspension array technology. Demographic data and clinical information were collected for statistical analysis.Results:The total detection rate of HPIVs in 5 448 children with CAP was 8.83% (481/5 448), and the detection rate in males was higher than that in females (62.79% vs. 37.21%; χ2=0.000, P=0.992). The detection rate of HPIVs in 1~< 3 years age group was higher than that in other age groups, and the difference was statistically significant ( χ2=61.893, P<0.001). The detection rate of HPIVs in the northern region was higher than that in the southern region (9.02% vs 8.65%), but the difference was not statistically significant ( χ2=0.239, P=0.625). The prevalence of HPIV1-4 in northern and southern China was not completely same. HPIV1 was mainly prevalent in autumn in both northern and southern regions. HPIV2 was prevalent in summer in northern China, and the detection rate was low in southern China. HPIV3 reached its peak in both spring and summer in both northern and southern China, but its duration was longer in southern China than in northern China. HPIV4 is mainly popular in autumn in both southern China and northern China. Among 481 children infected with HPIVs, 58.42% (281/481) were infected with HPIV alone, and the main clinical manifestations were cough (90.75%) and fever (68.68%). Out of the HPIV-positive cases, 42.62% (205/481) were co-infected with another type of HPIV or a different virus, while 11.43% (55/481) had co-infections with two or more different viruses. HPIV3 was the most common type of co-infection with other viruses. HPIV3 infection accounted for the largest proportion (76.80%) in 47 HPIVs-positive children with severe pneumonia. Conclusions:HPIVs is one of the most important pathogens causing CAP in children in China, and children under 3 years of age are the main populations of HPIVs infection. The prevalence characteristics of all types of HPIVs in children in the north and south are not completely same. HPIV3 is the dominant type of HPIV infections and causes more severe diseases.
