Research status and prospect of metagenomic sequencing for the screening of blood transfusion transmitted pathogens

VernacularTitle:宏基因组测序用于输血传播病原体筛查的研究现状与展望
Author: Zhengang SHAN ¹ ; Min WANG ; Ru XU ; Qiao LIAO ; Jieting HUANG ; Huishan ZHONG ; Yongshui FU ; Xia RONG
Author Information

1. 广州血液中心临床输血研究所，广州　510095
Keywords: Metagenome; High-Throughput sequencing; Blood donor; Blood screening
From: Chinese Journal of Experimental and Clinical Virology 2023;37(4):449-454
CountryChina
Language:Chinese
Abstract: Blood screening is essential for blood safety. Traditional methods are not very effective in unknown pathogen testing. The blood metagenomic analysis with high-throughput sequencing as the main method is not limited to a particular microbe but detects all microbes in the sample (total genome), which has advantages that traditional methods cannot compare with. With the increasingly maturation of technology and the gradual reduction of cost, metagenomic sequencing has been applied more and more widely. In this paper, the concept and research procedures of metagenomics, the current status and future prospect of metagenomics sequencing technology in the field of blood screening are reviewed.