Serum antibody level and diagnostic value in convalescent patients infected with novel coronavirus
10.3760/cma.j.cn112866-20230410-00037
- VernacularTitle:新冠病毒感染者恢复期血清抗体水平及诊断价值
- Author:
Feifei XING
1
;
Huanhuan FENG
;
Yu DU
;
Dan WEI
;
Yangguang DU
;
Jing TONG
Author Information
1. 徐州市疾病预防控制中心，徐州 221006
- Keywords:
Vaccine;
Novel coronavirus;
IgM;
IgG;
IgA;
Neutralizing antibody
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(4):404-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the levels of serum IgM, IgG, IgA and neutralizing antibodies (NAbs) in convalescing patients infected with the novel coronavirus and their diagnostic significance.Methods:Five hundreds and eighty one infected patients and 219 non-infected patients were detected by chemiluminescence method . The positive rate of antibody and antibody level were statistically analyzed for statistical significance. The correlation between the antibodies was compared, and the ability of each antibody to identify breakthrough infection in the vaccinated population was evaluated by combining ROC curve.Results:The antibody titers of IgM, IgG, NAbs and IgA in infected patients were higher than those in uninfected individuals. The antibody positive rate and antibody level of infected persons who were vaccinated and not vaccinated, with different ages, different doses of vaccines, and different intervals of vaccination were statistically significant ( P<0.05); IgA antibody levels were positively correlated with IgG and NAbs, and NAbs is positively correlated with IgG antibody; In breakthrough infection analysis, IgG, IgA and NAbs antibodies were good at identifying infected persons in the vaccinated population. Conclusions:The positive rate of IgM antibody is low in the convalescence period, which is of little significance for monitoring the course of COVID-19 and evaluating the efficacy of vaccines. In addition, the antibody level and positive rate can be significantly improved by the booster injection of COVID-19 vaccine. Differences in IgG, IgA, and NAbs antibody levels can be used to identify breakthrough infection cases from vaccinated populations.
