Progress in research of molecular mechanisms of pulmonary arterial smooth muscle cell pro-liferation
10.3969/j.issn.1673-4254.2013.12.32
- VernacularTitle:肺动脉平滑肌细胞增殖的分子信号机制研究进展
- Author:
Yuanyuan WU
1
;
Guizuo WANG
;
Manxiang LI
Author Information
1. 西安交通大学医学院第二附属医院呼吸病研究室//呼吸内科
- Keywords:
pulmonary hypertension;
pulmonary vascular remodeling;
smooth muscle cells;
molecular mechanisms
- From:
Journal of Southern Medical University
2013;(12):1852-1855
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension (PAH) is a common clinical syndrome characterized by elevated pulmonary arterial pressure. The pathological changes in PAH include increased vasoconstrictor tone, thrombosis in situ and pulmonary vascular remodeling. Pulmonary arterial smooth muscle cell (PASMC) proliferation is a hallmark of pulmonary vascular remodeling, and exploration of the molecular mechanisms of PASMC proliferation and intervention of the involved signaling pathways is therefore of great importance for prevention and treatment of PAH. This review focus primarily on the current understanding of the molecular mechanisms involved in the proliferation of PASMCs.
