Expression of ICAM-1 in Colorectal Carcinoma and Its Clinical Significance
10.3321/j.issn:1000-467X.2001.03.021
- VernacularTitle:大肠癌ICAM-1的表达及临床意义
- Author:
Ming-Zhi YANG
1
;
Ji-Sheng CHEN
;
Heng WU
;
Pei-Ge WANG
;
Jing-Zhi ZHANG
;
Yu-Jun LI
Author Information
1. Sun Yat-sen Memorial Hospital
- From:Chinese Journal of Cancer
2001;20(3):311-313
- CountryChina
- Language:Chinese
-
Abstract:
Objective：This study was designed to determine the expression of ICAM-1 in colorectal cancer and its clinical significance. Methods：The expression of ICAM-1 in 55 samples of colorectal carcinoma and 8 samples of adenomas were invested using immunohistochemical staining. Results：There were 41 positive cases in 55 colorectal cancer samples. The positive rate of ICAM-1 in colorectal cancer was significantly higher than that of adenomas （ P<0.05） , ICAM-1 in colorectal cancer was significantly correlated with lymph node metastasis. However， there was no significantly difference in ICAM-1 expression between adenomas and colorectal cancer without lymph node metastasis. Conclusion： Over-expression of ICAM-1 was significantly related to lymph node metastasis.
