Application of Bergman Parameter in Diagnosis of Lung Cancer
10.3321/j.issn:1000-467X.2001.03.020
- VernacularTitle:Bergman指数在肺癌诊断中的应用
- Author:
Bo-Hang ZENG
1
;
Hui HUANG
;
Xian YU
;
Yong-Jian WU
;
Dan LI
;
Jia-Chun LU
Author Information
1. Tumor the Second Affiliated Hospital
- From:Chinese Journal of Cancer
2001;20(3):308-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective：This study was designed to evaluate the application of three markers in diagnosing lung cancer and calculate Bergman Parameter to raise the sensitivity and validity in detecting the lung cancer. Methods：Using immunoradiometric and chemiluminescence assay, we observed serum NSE (neuron-specific enolase), CEA (carcinoembryonic antigen), and CA50(cancer-associated carbohydrate antigens 50) in 107 cases of lung cancer and 118 cases of benign pulmonary diseases. Bergman parameter was calculated with Bergman’s formula. Results：The sensitivity of NSE, CEA, CA50 for lung cancer were 51.4％ , 54.2％ , and 31.7％ , respectively. The specificity was 85.7％ , 89.8％ , and 93.0％ , respectively, while diagnostic accuracy rates were 64.3％ , 72.9％ , and 55.8％ . The sensitivity, specificity and diagnostic accuracy rate of Bergman parameter (95.2％ , 87.5％ and 92.1％ ) were higher than these three markers in lung cancer (P<0.05). We found that Bergman parameter could be used to moniter the prognosis of advanced lung cancer. Conclusion： Serum NSE, CEA, and CA50 are of value in detecting lung cancer. Bergman parameter, calculated with NSE, CEA, CA50, is able to increase specificity and accuracy in diagnosis of lung cancer.
