Effects of Early Enteral Nutrition on T-lymphocyte Subsets in Postoperative Patients with Gastrointestinal Carcinoma
10.3321/j.issn:1000-467X.2001.03.016
- VernacularTitle:早期肠内营养对胃肠癌患者术后T淋巴细胞亚群的影响
- Author:
Qiang-Pu CHEN
1
;
Yue-Li XING
;
Kun OU
;
Hong-Mei ZHAO
Author Information
1. Affiliated Hospital Binzhou Medical College
- From:Chinese Journal of Cancer
2001;20(3):294-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective：This study was designed to investigate the effects of early enteral nutrition(EN)on T-lymphocyte subsets in postoperative patients with gastrointestinal carcinoma. Methods：Fourty-five patients with gastrointestinal carcinoma were divided into three groups at random after radical resections：control group, PN (parenteral nutrition) group, and EN group. The changes of T-lymphocyte subsets were determined by APAAP (alkaline phosphatase anti-alkaline phosphatase) method before operation and at postoperative day 1,3,6 and 9. Results：The numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio decreased significantly, and CD8 cell number increased markedly in the control group and PN group after operation. In EN group, the numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio decreased significantly at the 1st day after operation, but then recovered gradually from the 3th day after operation. The numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio in EN group were higher than those of in the control group and PN group at the 3th, 6th, 9th day after operation (P<0.05). Conclusions： Early enteral nutrition can improve T-lymphocyte immune function in postoperative patients with gastrointestinal carcinoma.?
