Evaluation of the residual risk of HIV transmission through blood transfusion after nucleic acid testing in blood centers in China
10.3760/cma.j.cn112866-20230320-00029
- VernacularTitle:对我国血站实施核酸检测后输血传播HIV残余风险度的评估
- Author:
Yanhong WAN
1
;
Zhijun ZHEN
;
Ying LI
;
Yanqin HE
;
Feng YAN
;
Dongmin ZHANG
;
Shouguang XU
;
Nan WU
;
Kejin LI
;
Youhua SHEN
;
Lin BAO
;
Xiaoli CAO
;
Xia DU
;
Jianling ZHONG
;
Weiping FENG
;
Peng WANG
;
Ying LI
;
Dong GUO
;
Yang LIU
;
Li LI
;
Xinyan FAN
;
Junbing ZHOU
;
Xiaotong SUN
;
Lijun ZHOU
;
Liping NENG
;
Bing JU
;
Fang WANG
;
Yan QIU
Author Information
1. 太原市血液中心，太原 030024
- Keywords:
Blood transfusion;
HIV;
Window period;
Residual risk;
First donor;
Repeated donor
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(4):361-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the residual risk (RR) of transfusion transmitted HIV (TT-HIV) after the implementation of nucleic acid amplification test (NAT) in blood screening test among blood centers in China.Methods:The data of blood donors and HIV infection markers from 2017 to 2020 were collected from 28 blood centers via the Platform of Comparison of blood establishments Practice in Chinese Mainland. The new infection rate/window period mathematical model was used for two types of blood screening strategies, namely, two rounds ELISA plus individual NAT take turn with pooling NAT (2ELISA+ ID-NAT/MP-NAT) and two ELISA plus one round pooling NAT (2ELISA+ MP-NAT), and the RR of HIV infection was estimated also based on first donors (FDs) and repeated donors (RDs) in different blood donation years. T-test analyses were conducted for comparing TT HIV RR among FDs and RDs in different blood donation years with two blood screening strategies, and the variation trend of RR in HIV test was observed.Results:From 2017 to 2020, the RR of FDs in 2ELISA+ ID-NAT/MP-NAT blood screening strategy was 2.869/10 6 person-year, 3.795/10 6 persons-year, 3.879/10 6 person-year, and 2.890/10 6 person-year respectively. The RR of RDs was 1.797/10 6 person-year, 1.502/10 6 person-year, 1.857/10 6 person-year, and 1.483/10 6 person-year respectively. Significant difference exists between RR of FDs and RDs, with F=9.898 and p<0.05. In 2ELISA+ MP-NAT strategy, the RR of FDs was 3.508/10 6 person-year, 1.868/10 6 person-year, 2.204/10 6 person-year, and 1.765/10 6 person-year respectively. The RR of RDs was 0.948/10 6 person-year, 0.926/10 6 person-year, 0.748/10 6 person-year, and 0.682/10 6 person-year respectively. Statistical difference existed between RR of FDs and RDs, with F=17.126 and P<0.05. There was no significant difference between the RR of FDs in these two strategies with F=3.493 and P>0.05, while there was a difference between the RR of RDs in these two strategies with F=24.516 and P<0.05, and a difference between the RR of total donors (TDs) in these two strategies F=20.216 and P<0.05. Conclusions:The RR of TT HIV significantly decreased after the introduction of NAT into blood test among blood centers in China. There were some differences in the RR of HIV testing among different blood screening strategies. There could be significant differences in the RR of HIV testing among different groups of blood donors. Compared with FDs, RDs is the low risk group for HIV.
