Analysis of clinical manifestations and magnetic resonance imaging characteristics of 110 children with juvenile idiopathic arthritis
10.3760/cma.j.cn112866-20230622-00067
- VernacularTitle:110例幼年特发性关节炎患儿临床表现及磁共振成像特征分析
- Author:
Min KANG
1
;
Gaixiu SU
;
Yingjie XU
;
Ming LI
;
Yang YANG
;
Jianming LAI
Author Information
1. 首都儿科研究所附属儿童医院风湿免疫科，北京 100020
- Keywords:
Juvenile arthritis idiopathic;
Clinical manifestation;
Magnetic resonance imaging
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(3):326-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical manifestations and magnetic resonance imaging (MRI) features of knee joint involvement in children with Juvenile idiopathic arthritis (JIA).Methods:The clinical and laboratory data of 110 JIA patients with knee involvement in the Children′s Hospital Affiliated to Capital Institute of Pediatrics from January 2017 to October 2019 were collected and scored according to the JIA MRI scoring system. The clinical indicators, course of disease and MRI scores of different subtypes of JIA were compared, and the MRI improvement of the affected knee joint before and after treatment was evaluated.Results:Among the 110 JIA patients, 35 cases (31.8%) had infections, including 9 cases (8.2%) with tuberculosis infection, 12 cases (10.9%) with EB virus infection, and 14 cases (12.7%) with elevated anti-streptolysin O; there were 101 cases (91.8%) of synovial hyperplasia, 99 cases (90.0%) of joint effusion, 18 cases (16.4%) of bone marrow edema, 16 cases (14.6%) of cartilage injury, and 2 cases (1.2%) of bone erosion. Synovial hyperplasia and joint effusion were the main MRI findings of the affected knee in each subtype, and the suprapatellar bursa is the most common involved site. After treatment, the signs of synovial hyperplasia, joint effusion, and bone marrow edema improved, and the MRI scores significantly decreased compared with those before treatment ( P=0.001, 0.001, 0.001, all P<0.05), cartilage damage and bone destruction were not improved. Conclusions:During the diagnosis and treatment of JIA, attention should be paid to the screening of various pathogenic infections and treatment. MRI imaging of knee joint involvement in JIA mainly shows synovial hyperplasia and joint effusion. MRI score can help further understanding of joint lesions, and it is also an important reference index for treatment evaluation of JIA children.
