Clinical Pathological Characteristics of Malignant Lymphoepithelial Lesion of the Salivary Glands and Its Relationship with EB Virus
10.3321/j.issn:1000-467X.2001.03.010
- VernacularTitle:涎腺恶性淋巴上皮病变临床病理特征及其与EB病毒的相关性
- Author:
Hui-Lan RAO
1
;
Jing-Hui HOU
;
Yi-Li HUANG
;
Ya-Ping HAO
;
Hui-Zhong ZHANG
;
Jian-Yong SHAO
;
Han-Liang LIN
Author Information
1. Sun Yat-sen University of Medical Sciences
- From:Chinese Journal of Cancer
2001;20(3):270-273
- CountryChina
- Language:Chinese
-
Abstract:
Objectives：This study was designed to investigate the clinical pathological characteristics of malignant lymphoepithelial lesion(MLEL) of salivary glands and the relationship with EBV（ Epstein-Barr Virus） . Methods：In situ hybridization and immunohistochemical methods were used to detect EBERs (EBV-encoded small RNAs), latent membrane protein 1 (LMP1), EBNA2(EB nuclear antigen-2), and ZEBRA (Z EBV replication activator) in paraffin embedded tissues of 41 MLEL cases. Results：(1)Forty cases of MLEL showed staining with EBERs. Positive rate of EBERs by in situ hybridization in 41 cases of MLEL was 97.56％ . (2)LMP1 expression was detected in 75.6％ (31/41), positive rate of ZEBRA was 2.5％ (1/41), no EBNA2 was found (0/20). Conclusion：EBV might play an important role in pathogenesis of MLEL.
