Value of PCNA Expression in Predicting Advanced Epithelial Ovarian Cancer Chemotherapy Efficiency
10.3321/j.issn:1000-467X.2001.02.019
- VernacularTitle:增殖细胞核抗原表达在晚期卵巢上皮癌化疗效果中的预测价值
- Author:
Duo YIN
1
;
Xiu-Qin LI
;
Jing-Ming LU
Author Information
1. 中国医科大学
- From:Chinese Journal of Cancer
2001;20(2):195-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The current study was designed to investigate the relationship between the proliferating cell nuclear antigen(PCNA) expression and the effect of chemotherapy in the patients with advanced epithelial ovarian cancer. Methods: The samples were selected at epithelial ovarian cancer Stage Ⅲ /Ⅳ , who received more than 6 courses of postoperational chemotherapy, and showed effective (chemotherapy-effective group,28 cases). Immunohistochemical SP method was used to detect the expression of PCNA protein. Result: The expressions of PCNA in chemotherapy-effective and chemotherapy-ineffective were 32.14± 19.27％ ,23.18± 16.38％ (P<0.05), respectively. Conclusion: The expression of PCNA were different in epithelial ovarian cancer with different response to chemotherapy, and it may serve as a predicting factor of chemotherapy efficiency in epithelial ovarian cancer.
