Research progress in application of purified Vero cell rabies vaccine
10.3760/cma.j.cn112866-20221117-00234
- VernacularTitle:纯化Vero细胞狂犬病疫苗应用研究进展
- Author:
Haitian SUI
1
;
Yu GUO
;
Qian ZHANG
;
Zhongnan YANG
;
Jinfeng SU
;
Yang ZHANG
;
Wenwu YIN
;
Xiang SHU
Author Information
1. 中国生物技术股份有限公司，北京 100024
- Keywords:
Rabies;
Purified Vero cell rabies vaccine;
Safety;
Immunogenicity
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(2):208-215
- CountryChina
- Language:Chinese
-
Abstract:
The purified Vero cell rabies vaccine (PVRV) has been used in rabies prevention for more than 40 years. A comprehensive review of the relevant researches on PVRV in rabies prevention at local and overseas in recent years shows that in the simplified Zagreb immunization program, PVRV has the similar immunogenicity and safety as in the standard Essen program. PVRV, purified chicken embryo cell rabies vaccine (PCECV) and human diploid cell rabies vaccine (HDCV) have similar immunogenicity and safety. PVRV also has good immunogenicity and safety in special populations such as those with diseases. The combined vaccination of PVRV and acellular diphtheria, tetanus, pertussis and inactivated poliomyelitis combined vaccine (DTP-IPV) or others did not find immune interference, which provided feasibility for children to vaccinate against rabies at the same time of vaccinating with planned vaccines. The combination of PVRV and equine rabies immunoglobulin can also achieve better prevention effect. PVRV plays an important role in the prevention of rabies, and its wide application will make a positive contribution to achieving the goal of eliminating rabies transmitted from dogs to humans by 2030 proposed by World Health Organization (WHO).
