Expression of Epithelial Cadherin and Its Significance in Salivary Tumor
10.3321/j.issn:1000-467X.2001.02.018
- VernacularTitle:涎腺肿瘤表皮粘附因子的表达及其临床意义
- Author:
Wen-Chuan ZHAO
1
;
Hua CHEN
;
Yan-Xue LIU
;
Chun HUANG
;
Yi-Gong LI
;
Ju-Xin ZHANG
;
Yu-Hua ZHANG
Author Information
1. Cancer Hospital Tianjin Medical University
- From:Chinese Journal of Cancer
2001;20(2):191-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The current study was designed to explore the relationship between the epithelial cadherin (E-cd) expression and clinical appearances of salivary tumor. Method: The paraffin embedded tissue specimens were studied immunohistochemically using the ployclone antibody against E-cd and ABC method. The E-cd expression level was determined semiquantatively. The semi-quantitative parameters of E-cd expression were analyzed retrospectively with the clinical information. Result: The E-cd positive expressions were normal (＋ ＋ ) in two cases of normal salivary tissue, 5 cases of benign mixed tumor and paracancerous salivary tissue, 39 cases of of 47 malignant salivary malignancies it was decreased even to no E-cd expression. There was a significant correlation between decreased E-cd expression and preoperative clinical appearances, postoperative survival, recurrence or metastasis. Conclusion: The E-cd expression level may be a useful prognostic parameter for salivary malignancies.
