Significance of Functional Inactivation of p53 in Esophageal Squamous Cell Carcinoma
10.3321/j.issn:1000-467X.2001.02.017
- VernacularTitle:p53功能失活在食管鳞癌中的表达及意义
- Author:
Xiao-Dong LI
1
;
Tie-Hua RONG
;
Jian-Hua FU
;
Hao LONG
Author Information
1. Sun Yat-sen University of Medical Sciences
- From:Chinese Journal of Cancer
2001;20(2):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective： The current study was designed to establish a new method to evaluate biological activity of carcinoma— functional status of p53, and investigate the relationship between functional inactivation of p53 and the TNM(tumor,nodes,metastasis) staging or histological classification of squamous cell carcinoma of esophagus. Methods： A total of 45 samples of fresh esophageal tissues of squamous cell carcinoma and normal esophageal tissues were examined for functional inactivation of p53 by detection of functional inactivation of p53 ( comparison with detection of p53 gene mutation ) . Then the analyses of detected results and the TNM stagings or the histological classifications of the carcinoma were statistically analyzed in SPSS. Results： The rate of functional inactivation of p53 (64％ ) seemed to be obviously higher than that of p53 gene mutation (49％ ) with a significant difference (P=0.046). There was a significant relationship between functional inactivation of p53 and the TNM staging of esophageal squamous cell carcinoma. Its rate tended to be increased with the advance of the TNM staging; there was a significant relationship between functional inactivation of p53 and the histological classification. With the advance of the histological classification, the rate of functional inactivation of p53 could have increased. Conclusions： The functional inactivation of p53 would be expected to be a new method to evaluate the biological activity of esophageal squamous cell carcinoma； there was a significant relationship between functional inactivation of p53 and the TNM staging or the histological classification.
