Effect of high-intensity focused ultrasound combined with gemcitabine on subcutaneous pancreatic cancer in nude mice
10.3969/j.issn.1673-4254.2013.12.01
- VernacularTitle:高强度聚焦超声联合吉西他滨对裸鼠胰腺癌皮下移植瘤的疗效
- Author:
Ying MAO
1
;
Liaoqiong FANG
;
Longxing LIU
;
Haixia HU
;
Faqi LI
;
Hui ZHU
Author Information
1. 重庆医科大学生物医学工程学院//省部共建超声医学工程国家重点实验室//超声医学工程重庆市市级重点实验室
- Keywords:
high-intensity focused ultrasound;
pancreatic cancer;
gemcitabine
- From:
Journal of Southern Medical University
2013;(12):1713-1717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of high-intensity focused ultrasound (HIFU) and gemcitabine on xenograft growth in nude mice bearing human pancreatic cancer. Methods Nude mouse models bearing subcutaneous human pancreatic cancer cell line PANC-1 xenograft were randomized into 4 groups, including a control group and 3 treatment groups subjected to treatments with HIFU, gemcitabine, or both. After the treatments, the tumor was measured on a weekly basis for 5 weeks, and the tumor growth curve was drawn. The tumor inhibition rate was calculated and the expression of vascular endothelial growth factor (VEGF) in the tumor tissue was examined by immunohistochemistry. Results The tumor volume showed significant differences between the 3 treatment groups (P<0.01), but all significantly smaller than that in the control group; HIFU combined with gemcitabine resulted in the most obvious reduction in the tumor volume. VEGF expression in the tumor tissue was the lowest in the combined treatment group and the highest in the control group. Conclusion HIFU therapy produces definite therapeutic effect on human pancreatic cancer in the nude mouse model, and its combination with chemotherapy is the optimal treatment modality.
