Research progress on the application of CRISPR/Cas system in molecular detection of 2019 novel coronavirus
10.3760/cma.j.cn112866-20220727-00168
- VernacularTitle:CRISPR/Cas系统在新型冠状病毒分子检测中的应用研究进展
- Author:
Meihui LUO
1
;
Wenling WANG
;
Wenjie TAN
Author Information
1. 中国疾病预防控制中心病毒病预防控制所，北京 102206
- Keywords:
2019-nCoV;
COVID-19;
CRISPR/Cas system;
Detection
- From:
Chinese Journal of Experimental and Clinical Virology
2023;37(1):112-119
- CountryChina
- Language:Chinese
-
Abstract:
The outbreak of Coronavirus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (2019-nCoV) has caused serious public health problems worldwide. Variants of 2019-nCoV with varied virulence and transmissibility have caught attention continuously. Fast, accurate and effective detection methods play a crucial role in the control and prevention of COVID-19 pandemic. Clustered regularly interspaced short palindromic repeats (CRISPR) and related proteins (CRISPR-associated, Cas) based nucleic acid detection methods are characteristic with high specificity and sensitivity, speediness, portability and low price. They have the potential as a candidate one to be used in the molecular detection of 2019-nCoV. The application of CRISPR/Cas system in the detection of 2019-nCoV was reviewed here as a reference for the control and prevention of COVID-19.
